Set up his private den. He needs "a room of his own." From the earliest possible moment give your pup or dog his own, private sleeping place that's not used by anyone else in the family, or another pet. He'll benefit from short periods left alone in the comfort and safety of his den. Reward him if he remains relaxed and quiet. His den, which is often a crate, will also be a valuable tool for housetraining.
Any area that the pup has access to must be kept clear and clean. Put out of puppy's reach anything you don't want him to chew or destroy. Do not allow your puppy to have unsupervised access to 'unchewables.' Do not chase the puppy in an attempt to take something away. Instead provide puppy with her own toys and teach her how to play with them exclusively.